01 · The GapWhat standard testing leaves out

You can't work on what you can't see.

Much of what shapes how well you age (your membranes, your mitochondria, your brain structure, the quiet shifts that begin long before you would notice them) sits outside the range of a standard blood test or a basic MRI.

The science is not new. Researchers have published on it for thirty years. The technology to measure it exists. It has been studied in research trials, peer-reviewed in major journals, and used in academic labs for decades.

It just never made it to you.

02 · Image
Image
Microscopy or scientific imaging suggesting biological processes
Fluorescent microscopy · 3:4 portrait
What's happening · Right now · Inside you

The processes that will shape your next thirty years (membrane integrity, mitochondrial output, methyl economy, cortical structure) are running quietly in your body as you read this.

You will not feel them shifting. You will not notice the drift. The point of BioMetrix is to see that trajectory now, while it can still be influenced.

“We don't suffer from a lack of scientific knowledge. We don't suffer from a lack of really good scientific technology. We suffer from the ability to actually implement it in everyday people's lives.”
Dr. Dayan Goodenowe, PhD

That's what the BioMetrix Suite is for.

02 · The SuiteThree tools · One continuum

Three tools. One continuum.

Each technology stands on its own. Designed together, they form a loop. Measure the biochemistry, see the brain, support what the measurements show, measure again. A system of self-directed research that lived only inside a research lab. Until now.

01 · Measure
BioMetrix™

Your biochemistry, measured.

A single blood draw. Over 40 biomarkers across 17 panels. The biochemistry of your membranes, mitochondria, methyltransferase system, and muscle, measured at the resolution research labs use.

Explore BioScan →
03 · Image
Image
BioScan report close-up or blood-sample editorial photography
Sample vials · or report detail · 4:3
02 · See
BioMetrix™

Your brain, seen.

A comprehensive 3T brain MRI. Seven imaging technologies in a single session: volumetric, microstructural, biochemical, vascular. Hundreds of regions, measured the way academic neuroimaging labs measure them.

Explore NeuroMRI →
04 · Image
Image
Brain MRI section, sagittal or axial, real radiological imagery
T1 weighted · greyscale · 4:3
03 · Support
BioNutrix™

The biochemistry, supported.

The targeted nutritional protocol built around the same biochemistry BioScan measures. Plasmalogen precursors, animal-source phosphocholine, methyl donors, mitochondrial cofactors. Each component has a defined role.

Explore NeuroRestore →
05 · Image
Image
BioNutrix NeuroRestore protocol arranged flat-lay, editorial photography
Bottles + measuring cups · overhead · 4:3
The full continuum · in the loop

Measure. See. Support. Measure again.

See the full loop →
03 · BioMetrix BioScanMeasure · Biochemistry
Measure

BioMetrix
BioScan

Your biochemistry, in research-grade resolution.

A standard blood test gives you a dozen numbers a clinician uses to flag illness. BioScan measures the molecules that decades of research associate with how the body ages: plasmalogens, phosphocholines, sphingomyelins, ceramides, GTAs. Measured all at once. From a single draw.

40+Biomarkers measuredPlasmalogens, phosphocholines, sphingomyelins, ceramides, oxidative-stress markers, methylation throughput.
17Distinct panelsEach panel maps to a system: membranes, mitochondria, methyl economy, muscle, recovery.
1Single blood drawFrom one standard sample, processed on FT-ICR-MS, a research-grade mass spectrometry platform.
How it works

Research-grade mass spectrometry, now measuring you.

BioScan runs on Fourier-Transform Ion Cyclotron Resonance Mass Spectrometry, one of the most precise mass spectrometry technologies available. Developed for systems-biology research, it is now turned toward something simpler: showing you what is in your blood.

Every molecule has a unique mass signature. FT-ICR-MS resolves molecules that differ by a few thousandths of an atomic mass unit. That is how it measures species a standard blood test does not distinguish.

11 · Image
Image
FT-ICR mass spectrometer photographed editorially
Clean studio shot · 3:2 landscape
The instrument

Roughly a dozen FT-ICR-MS instruments of this class are in research use in North America.

Most consumer blood testing runs on immunoassays and standard chromatography platforms that cannot resolve these molecules. It is not that other labs chose to skip plasmalogens. The equipment to measure them is not on their menu.

The Framework

The Four M's of metabolic health.

After thirty years of research across aging and metabolic biology, four systems keep showing up as the most informative about everything else. BioScan measures them all, and each measurement informs the others.

M1 · Cellular boundaries

Membranes.

“Every signal, every hormone, happens at a membrane.”

The physical structure of every cell in your body. Membrane composition shapes how well your cells respond to stress, inflammation, and aging. The lipidomics the consumer testing industry does not measure.

  • Plasmalogens (PLE/PLC)
  • Phosphatidylethanolamines
  • Phosphatidylcholines
  • Sphingomyelins
  • Ceramides
  • ω-3 / ω-6 index
  • Lysolipids
  • GTAs
07 · Image
Image
Cell membrane microscopy or phospholipid bilayer render
M2 · Energy & oxidative load

Mitochondria.

“Every ounce of fatigue you've felt was a mitochondrion that couldn't keep up.”

Mitochondrial output and the oxidative stress that comes with inefficient combustion. Mitochondrial phospholipid species reflect how well your mitochondria process energy, not just how many you have.

  • hsCRP
  • Malondialdehyde
  • Catalase · SOD
  • Galectin-3
  • Cortisol
  • PE 38:4 · PC 40:4
  • Total iron
08 · Image
Image
Mitochondria electron microscopy · cristae visible
M3 · The body's build system

Methyltransferase.

“Most labs measure the warning light. We measure the whole system.”

Methyl groups are how your body makes phosphatidylcholine, creatine, neurotransmitters, and the regulators that keep your nervous system functioning. Capacity, throughput, and load, measured together.

  • Total PE · PC
  • Total SM · Ceramides
  • Homocysteine
  • Creatinine
  • PE / PC ratio
  • ω-3 / ω-6 ratio
09 · Image
Image
Methylation pathway diagram or SAM molecular render
M4 · Recovery capacity

Muscle & recovery.

“Muscle mass is one of the strongest markers tracked in aging research.”

Kidney-function markers that reflect muscle integrity, plus the peroxisomal function that supports how well your body recovers and builds. The recovery system, measured directly.

  • Creatinine
  • Creatine kinase
  • BUN · Uric acid
  • DHA-PE · EPA-PE
  • DHA-plasmalogen · EPA-plasmalogen
  • Triacylglycerols
10 · Image
Image
Muscle tissue histology, cross-section under polarized light
What BioScan measures

A sample BioScan report. Browsable.

A standard wellness panel measures cholesterol, glucose, vitamin D, and a few dozen routine markers. BioScan adds the markers metabolomics research associates with how the body ages, many of which most consumer labs do not report.

Illustrative sample below. Values shown are for layout only. Click any row for detail.

“If you don't know your plasmalogen levels, if you don't know your phosphocholine levels, if you don't know your methyltransferase system, you are in the dark as to what's going on inside your body.”
Dr. Dayan Goodenowe, PhD

The science behind the markers on the BioScan panel has been published, peer-reviewed, and studied across large population cohorts, much of it twenty years ago or more. The research has been there the whole time. BioScan is what happens when that research finally becomes a test you can take.

04 · BioMetrix NeuroMRISee · Brain structure & microstructure
See

BioMetrix
NeuroMRI

Your brain, the way research labs see it.

A standard MRI takes a picture. NeuroMRI runs seven different imaging technologies in a single session and produces a measurement of your brain's structure, microstructure, and function down to hundreds of individual regions. The difference between looking at a photograph and reading an MRI the way a research scientist does. NeuroMRI is always optional and available at additional cost.

The session

Seven modalities. One session.

Each modality has been validated in peer-reviewed research for twenty to thirty years. Each is standard equipment in academic neuroimaging labs. Few consumer brain MRI offerings bring them together in one session.

01

T1 Structural

The foundation. Gray matter, white matter, ventricles, CSF, at sub-millimeter resolution.

13
02

T2 FLAIR

Highlights white-matter hyperintensities and small features standard sequences miss.

14
03

T2 SWAN

Susceptibility weighting. Microbleeds and iron deposits no other sequence shows.

15
04

DTI

Diffusion Tensor Imaging. Maps the white-matter pathways connecting every region to every other.

16
05

NODDI

Three water signals separated (inside axons, around cell bodies, free water) to measure tissue microstructure.

17
06

ASL

Arterial Spin Labeling. Cerebral blood flow measured directly. No contrast dye required.

18
07

MRS

Magnetic Resonance Spectroscopy. The biochemistry of frontal cortex and precuneus.

19
What NeuroMRI shows you

What most longevity scans don't measure.

Consumer brain MRI has been having a moment: scans that look for structural findings and report basic brain volumes. NeuroMRI is a different category. Here is what it shows you that those scans typically don't.

17
01Neurite density across your whole brain (NODDI)
The structural integrity of your brain's wiring, measured by separating three water signals. One of the most sensitive measurements of brain aging in the research literature, and one most consumer brain MRI offerings do not include.
19
02Brain biochemistry via MR spectroscopy
A non-invasive measurement of neurochemical concentrations in two regions, frontal cortex and precuneus. Used in academic research for decades. Rarely part of a longevity brain MRI bundle.
13
03600-region cortical surface mapping
Most quantitative brain MRI tools report 30 to 100 regions. NeuroMRI reports 600 fine-grained cortical regions using the Schaefer-Yeo atlas research labs use.
16
04Whole-brain white matter connectivity
A measurement of connection strength between every brain region and every other. Shows how the wiring is holding up, not just whether it looks intact.
18
05Cerebral blood flow without contrast dye
ASL measures how well blood reaches every region of your brain, without an injection of contrast material.
The aging brain

From age 40 to age 60, the average healthy adult changes this much.

None of this shows up on a standard MRI. All of it is visible, and quantified against population norms, on NeuroMRI.

20
Gray matter
Cortical & subcortical
−14%
21
White matter
Connective tracts
−11%
22
Cerebrospinal fluid
Compensatory expansion
+36%
23
Ventricular volume
Lateral ventricles
+87%

1 Yamada et al. European Radiology 2023; 33:7099–7112. n=4,651 healthy adults, age 21–80.

25
The cortex begins changing, measurably, by age 40, at roughly this rate per year.
0.3–0.5%
Cortical thinning per year, age 40+ · Storsve 2014, Fjell & Walhovd 2010 · meta-analysis
The viewer

Your brain, region by region.

Hover any region to see its percentile against population norms. Toggle modalities to see what each adds. The viewer below uses placeholder imagery; hotspots and controls are live. In the final build, the cortical surface rotates slowly when idle.

What the measurements say

The trajectory is not necessarily fixed.

Brain aging is often described as one-way. Research suggests it may be more responsive than that. With the right nutritional inputs, the trajectory may shift, and you will have the baseline scans to see whether yours did.

That is the point of NeuroMRI. Not only to see the picture, but to give you a baseline you can return to.

“You can't go back and change your past. But you can influence the trajectory you're on. That's what we're here to show you.”
Dr. Dayan Goodenowe, PhD
05 · BioNutrix NeuroRestoreSupport · Targeted nutrition
Support

BioNutrix
NeuroRestore

The biochemistry the scans measure, supported.

BioNutrix NeuroRestore is a targeted nutritional protocol built around the same biochemistry BioScan measures and NeuroMRI reveals. Plasmalogen precursors designed for oral delivery. Animal-source phosphocholine. Methyl donors. Mitochondrial cofactors. Each component has a defined job that maps directly to a panel on your BioScan.

26 · Image
Image
Full daily BioNutrix NeuroRestore protocol arranged compositionally
Editorial flat-lay · 16:9

The daily protocol · 15 components · organized by biochemical purpose

How it's built

Engineered, not stacked.

Most supplement stacks are a list of ingredients chosen because each one is "good for you." NeuroRestore is built backward from the biochemistry: the inputs your cells use to maintain membranes, make neurotransmitters, generate energy, and manage inflammation.

The plasmalogen precursors are designed for oral absorption. The phosphocholine is animal-sourced because plant-based forms do not deliver the same way. Every component has a job.

27 · Render
Render
Plasmalogen molecular structure, clean line drawing in accent teal
Visual signature

A plasmalogen, the molecule the NeuroRestore protocol is engineered to support.

Plasmalogens are ether-phospholipids that make up roughly 18 to 20% of the phospholipid mass of the human brain. The body's own synthesis tends to decline with age. The oral precursors in ProdromeNeuro are designed to support plasmalogen levels.

What's in the protocol

The daily protocol.

Organized by biochemical purpose. Each component has a defined job that maps to a panel on your BioScan.

Membrane support03 components
ProdromeNeuro™Omega-3 DHA plasmalogen precursor
ProdromeGlia™Omega-9 plasmalogen precursor for myelin
ProdromePC+™Animal-source phosphocholine (egg-yolk derived)
Methyl support02 components
B1, B2, B6, B9, B12Full methyl-donor cofactor support
Vitamin CAntioxidant cofactor
Mitochondrial support05 components
Acetyl-L-CarnitineFatty-acid transport
Alpha Lipoic AcidUniversal antioxidant
N-AcetylcysteineGlutathione precursor
BDMCBisdemethoxycurcumin · inflammation support
Ketone Ester (KE4)Backup energy substrate · by KetoneAid
Mineral & micronutrient02 components
ZincCofactor mineral
Magnesium MalateCofactor mineral
Muscle & recovery03 components
CreatineMuscle energy and methyl support
Hydrogen TabletsOxidative stress support
Muscle WaterElectrolyte support
“Your body has a certain capacity. It can make a thousand methyl groups, but it needs two thousand. So it has to choose. High homocysteine is telling you the load you're asking of your body is more than your biochemistry can deliver.”
Dr. Dayan Goodenowe, PhD

NeuroRestore is built around that capacity question. Provide the building blocks. Provide the energy. Let your body decide where to use them. Whatever shifts in your biochemistry, BioScan and NeuroMRI show it, in measurements you can see.

06 · The LoopWhere the continuum lives

Measure. See. Support. Measure again.

Each tool stands on its own. Together they form something few clinics or consumer labs make available: a closed measurement loop, where what you do today is observable in your biochemistry tomorrow.

Beat 01Measure your biochemistry. See your brain. Get a baseline you can return to.
Beat 02Support your biochemistry with a protocol built around the same molecules the scans measure.
Beat 03Measure again. Find out what shifted, in you, not in theory.
07 · The BackstoryWhy this didn't exist before
How this got built

The research has been done. The delivery hadn't.

FT-ICR-MS, NODDI, DTI, ASL, MRS. Every technology in the BioMetrix Suite has been validated in peer-reviewed research for twenty to thirty years. None of it is experimental. None of it is fringe. It is standard equipment in academic research labs.

The reason you have never been offered any of it is structural. Standard laboratories and MRI centers are built around the menu of tests insurance reimburses. Plasmalogen analysis is not on that menu. NODDI is not on that menu. To make this kind of measurement available to regular people, the delivery system had to be built from scratch: the labs, the imaging centers, the analysis pipelines.

That's what the BioMetrix Suite is.

31 · Image
Image
Research infrastructure detail: lab interior or Goodenowe lab notebook
Editorial · 16:9
Goodenowe research lab · Saskatoon · Calgary · Carlsbad
“Self-directed research is the model. You don't have the right to diagnose yourself or treat yourself. But you do have the right to have quantifiable information about what your blood looks like, what your brain looks like. That's what we built.”
Dr. Dayan Goodenowe, PhD